Histological classification and molecular genetics of meningiomas. Clincal information is rquired to distinguish between bone invasion and meningiomas with bone formation. To characterize histopathological and clinical features of angiomatous meningioma, 38 cases of angiomatous meningioma, ie, meningiomas whose vascular component exceeded 50% of the total tumor area, are reported. Intradural angiomatous meningioma arising from a thoracic. Webpathology is a free educational resource with 10295 high quality pathology images of benign and malignant neoplasms and related entities. A diagnostic dilemma sumit bansal1 ashok kumar mahapatra1 susama patra2 1department of neurosurgery, all india institute of medical sciences, bhubaneswar, odisha, india 2department of pathology and laboratory medicine, all india institute of medical sciences, bhubaneswar, odisha, india indian j neurosurg 2016. Angiomatous meningiomas, as their name suggests, demonstrate abundant blood vessels greater than 50% of the whole tumour. The main location of angiomatous meningioma was cerebral convexity and other locations included sphenoid wing, sellar region, cerebellopontine angle cpa, and tentorium of cerebellum. Muc4 expression was constant and almost diffuse in meningothelial and angiomatous subtypes, whereas it was limited in 5% or fewer tumour cells or absent in 26 of 28 fibrous meningiomas. Distinguishing chordoid meningiomas from their histologic. All other mesenchymal tumours examined were negative for muc4. Histopathological and immunohistochemical evaluation of meningiomas with reference to proliferative markers p53 and ki67 ramesh babu telugu, 1 amit kumar chowhan, 2 nandyala rukmangadha, 3 rashmi patnayak, 4 bobbidi venkata phaneendra, 5 bodapati chandra mowliswara prasad, 6 and mandyam kumaraswamy reddy 7.
The meningothelial component of the tumor may be difficult to discern amidst the vessels, which may be large or small. In addition to histologic examinations, clinical characteristics as well as followup data were compiled. Histopathology revealed an angiomatous meningioma with predominant microvascular component and extensive cystic changes. Preoperative assessment of meningioma aggressiveness by. Angiomatous meningioma, arachnoidal sheet, intradural meningioma, spinal nerve, spinal tumors. Anatomically, angiomatous meningioma is located most commonly over cerebral convexity and are dural based lesions 6. Angiomatous meningiomas are a rare histological variant of who grade i meningiomas and account for only 2. The age of patients ranged from 24 to 72 years with a mean of 51. In the present work, we report the clinical and radiological features with postoperative outcomes of angiomatous meningioma. The study of angiomatous meningioma has been mentioned in research publications which can be found using our bioinformatics tool below. A case report on cystic meningioma in cerebellopontine. Pdf angiomatous meningioma am is a rare histological variant of meningioma. Angiomatous meningioma in 49 years old male international.
Exposure to ionizing radiation, especially high doses, has been associated with a higher incidence of intracranial tumors, particularly. Meningioma is perhaps the primary neuroepithelial tumor with the widest diversification in histologic pattern. Although grade i subtype constitutes the highest portion of all meningiomas, angiomatous meningioma is of very rare. Histomorphological spectrum of meningioma with variants. Until now clinicopathologic characteristics of angiomatous meningioma have not been systematically analyzed and studied in detail except by martin et al. Angiomatous meningioma arising in tonsil international. Muc4 is expressed variably but almost consistently in meningiomas, particularly in meningothelial or angiomatous subtypes. Clinical study differentiation of benign angiomatous and. In their study, they found seizures and neurological deficit to be the common. Meningiomas classifications, risk factors, diagnosis and.
Perfusion imaging of meningioma by using continuous. Histomorphological spectrum of meningioma with variants and grading. A thin csf cleft is difficult to appreciate however is most conspicuous along the anterior aspect of the lesion with impression of cortical buckling. Disease bioinformatics research of angiomatous meningioma has been linked to meningioma, neoplasms, meningeal neoplasms, brain neoplasms, edema. Pdf clinical characteristics and treatment of angiomatous.
Some of these patterns may suggest a diagnosis other than meningioma, particularly when the biopsy sample is small and during intraoperative consultation. The appearances were felt to most likely represent a meningioma, although the very high t2 signal is not typical and suggests a histological variant. Angiomatous meningioma in 49 years old male a rare case. A slight male predominance may be a clinical characteristic, in contrast to the female predominance of typical meningiomas. According to simpson classification, 7, 5, and 3 patients were categorized as simpson grade i. Cystic angiomatous meningioma in the cerebellopontine angle. Angiomatous also belongs to the same subtype but comprises only 2. A meningioma is a tumor that forms on membranes that cover the brain and spinal cord just inside the skull specifically, the tumor forms on the three layers of membranes that are called meninges. Meningiomas in close proximity of venous sinuses had a 10year recurrence rate after radiologically radical removal of 40% versus 15%. Cystic meningioma located at the cerebellopontine angle cpa is an extremely rare occurrence. For benign meningiomas, clinically relevant recurrences are common during the patients lifetimes.
Twenty seven patients 14 male and female with angiomatous meningioma were treated in our institution. Clinical and radiological characteristics of angiomatous. Pathology of cutaneous epithelioid angiomatous nodule dr. Immunopositivity for epithelial membrane antigen ema, vimentin and s100 protein proved vital in excluding a hemangioblastoma. Pathologically, it was an angiomatous meningioma am. Angiomatous meningioma is a rare subgroup of meningiomas in which numerous vascular channels prevail on the background of an otherwise typical meningioma. The epidemiology and clinical presentation of these tumors do not clearly deviate from that of more common hist. Angiomatous meningioma in 49 years old male a rare case report gunvanti b. Angiomatous meningioma am is a rare histological variant of. Its immunohistochemical detection is useful to distinguish meningiomas from other intracranial or head and neck mesenchymal tumours, particularly those with epithelioid features. Angiomatous meningioma belongs to who grade i category and accounts for 2. The aims of our study was to determine the clinical characteristics, radiological features and prognosis of this rare meningioma subtype.
It is world health organization gradei histological subtype of meningioma having predominance of. African americans have been observed to have higher rates of meningioma than other ethnic groups in the u. The variants that usually are t2 hyperintense are microcystic, secretory, cartilaginous metaplastic chordoid and angiomatous. The dura is opened, and the meningioma can be seen extending en plaque over the surface of the brain. It has features of a typical benign meningioma with many small or large vascular channels which may predominate over its meningothelial. C, a world health organization grade ii, atypical meningioma with mitotic activity arrow, highlighted in the inset arrow. A radiologypathological correlation of spinal meningioma in. Differentiation of benign angiomatous and microcystic. A, angiomatous variant of meningioma with interspersed thickwalled vascular channels arrow. Tandan pathology department, sbks medical institute and research centre, sumandeep vidyapeeth, vadodara, gujarat, india corresponding author a b s t r a c t keywords all meningiomas. Oct 31, 2016 angiomatous meningioma is a rare histological subtype of meningioma. Cutaneous epithelioid angiomatous nodule cean was first described in 2004 by brenn and fletcher after a study of 15 cases.
Webpathology is a free educational resource with 10312 high quality pathology images of benign and malignant neoplasms and related entities. Article pdf available in indian journal of pathology and microbiology 511. This subtype of meningioma have similar clinical features as of benign meningiomas. Histopathological and immunohistochemical evaluation of. A meningioma is, in many ways, the soul of neurosurgery. The progress in meningioma treatment mirrors advances in neurosurgery, and advancements in neurosurgery are put to maximal use to improve the treatment of meningiomas. An eccrine angiomatous hamartoma with histopathological features of a papillary haemangioma in a neonate.
Typical, atypical, and misleading features in meningioma. Aug 15, 2018 muc4 was expressed in meningiomas 92. Histologically, am has numerous blood vessel channels and at least focal classic meningioma morphology. Angiomatous meningioma indian journal of pathology and. Adultonset eccrine angiomatous hamartoma on the vulva. Pthe histological appearance of a meningioma is an important predictor of tumor behavior and is frequently a factor in decisions concerning therapy. Angiomatous meningioma is a rare histological subtype characterized by the predominance of blood vessels, corresponding to who grade i. The relationship between histological features and prognosis is formalized in grading. Histopathological examination reveals distinctive charac. On histology, all tumors exhibited abundant blood vessels with at least focal. Vascular component should exceed 50% of total tumor area. In addition, a th variant, the rhabdoid meningioma, is now recognized and classified as grade iii, along with the papillary meningioma.
A radiologypathological correlation of spinal meningioma in a tertiary care hospital a retrospective study a g krishnaveni1, p kannan2, heber anandan3 1associate professor, department of pathology, thoothukudi medical college, thoothukudi, tamil nadu, india, 2professor and head. Primary extradural meningioma is a far more rare entity. Clinical study differentiation of benign angiomatous and microcystic meningiomas with extensive peritumoral edema from high grade meningiomas with aid of diffusion weighted mri avetisazizyan, 1 paulaeboli, 2 donieldrazin, 2 jamesmirocha, 3 marcelm. A 60yearold woman with middle skull base angiomatous meningioma. Histopathology of this tumor showed thin walled vascular channels and cells with bland morphology in the background. Eccrine angiomatous hamartoma is a lymphatic proliferation. By world health organization criteria, 46 histologic features of a meningioma that warrant grade ii designation include chordoid, clear cell, or atypical histology, the latter depicted as having.
Meningioma histology, pathology neuropathology neoplasm from meningothelial cells slides for the practical part of the pathology exam at masaryk universi. Hence, the copy number profiles of these two tumor types are distinct. Histomorphological spectrum of meningioma with variants and. P histopathology of meningioma the following 51 files are in this category, out of 51 total. Four of the samples of meningioma with angiomatous features mg116, mg1, mg162. The typical meningioma is a homogeneous, hemispheric, markedly enhancing extraaxial mass located over the cerebral convexity, in the parasagittal region, or arising from the sphenoid wing. It has features of a typical benign meningioma with many small or large vascular channels. Mar 15, 20 angiomatous meningioma am is a rare histological variant of meningioma.
Angiomatous meningiomas are a subgroup of meningiomas, in which numerous vessels prevail on the background of a typical meningioma. She received a simpson grade ii meningioma resection in 2005. A meningioma is a tumor that forms on membranes that cover the brain and spinal cord just inside the skull specifically, the tumor forms on the. Angioma tous meningioma is a rare variant of meningioma with few distinctive clinical, radiological and histopathological features and should be. Recurrence of meningiomas and its management clinical gate. The term angiomatous meningioma denotes a richly vascularized meningioma. Angiomatous meningiomas have a distinct genetic profile with. Angiomatous meningioma in 49 years old male a rare case report. Type 1 is the benign variant, in which meningothelial is the most common subtype. Little is known about the clinical features and outcome of this rare disease.
Angiomatous, cerebellopontine angle, cystic, meningioma. Histology of the different benign meningioma variants who grade i. Clinical characteristics and treatment of angiomatous. Abu khalid muhammad maruf raza1, ferdous ahmed 2, tajrin akter munni 3, zabed ahmed mitu4, shahriar masood5 1department of pathology, jahurul islam medical college, kishoregonj, bangladesh 2department of pathology, dhaka community medical college, mogbazar, dhaka, bangladesh. Angiomatous meningioma am is rare world health origination who grade i histological subtype of meningioma, comprising 2. Angiomatous meningioma is a rare histological subtype of meningioma. Angiomatous meningiomas have a very benign outcome despite.
The risk of meningioma increases with age with a dramatic increase after 65 years. Angiomatous meningioma is a rare subgroup of meningiomas in which numerous vascular channels prevail and constitute 2. On noncontrast ct, the tumor shows slightly high attenuation. When the vessels are capillary size, the tumor may resemble a hemangioblastoma. Angiomatous meningioma radiology reference article. Media in category histopathology of meningioma the following 51 files are in this category, out of 51 total. A 70yearold male presenting with progressive headache and gait disturbance. Angiomatous definition of angiomatous by medical dictionary.
Preoperative assessment of meningioma aggressiveness by thallium201 brain spect reza mirfallah 1. Case report we present a 40yearold patient who came in our clinic with persistent headache, palsy of the vii cranial nerve, and tonicclonic seizures. Seemingly complete removal is achieved in 64% to 97% of operated patients 1 5 but is curative only in 68% to 80%. To determine whether angiomatous and microcystic meningiomas which mimic high grade meningiomas based on extent of peritumoral edema can be reliably differentiated as low grade tumors using normalized apparent diffusion coefficient adc values. We herein report the results of a 15year multicenter experience of 58 successive cases of intracranial angiomatous meningiomas. Four cases of atypical meningioma and one case of papillary meningioma were observed table 3. Common sense holds that the risk of recurrence depends on the extent of removal. Meningiomas are classified into three types according to the world health organization classification system which is based on morphologic criteria. Unfortunately, the main differential for an angiomatous meningioma is a hemangiopericytoma, which used to be considered a variant of meningioma and went by the annoyingly similar name of angioblastic meningioma. Clinical characteristics and treatment of angiomatous meningiomas. B, chordoid meningioma with tumor cells arranged in cords, alternating with bluish myxoid stroma. Case report abstract angiomatous meningioma am is a rare histological variant of meningioma, accounts for 2. Their clinical presentation, neuroimaging studies, treatment and followup were investigated. Meningiomas may originate in unexpected locations such as the orbit, paranasal sinus, or ventricles or be entirely intraosseous within the calvaria.
945 1622 634 363 709 48 1309 370 851 1401 1280 1618 1266 562 784 252 666 1350 1339 484 387 953 1628 964 1109 64 655 63 1289 1603 466 155 1399 615 1062 990 635 362 1318 353 505 536 691 1181